The Hidden Truth About Multivitamins - Synthetic vs. Whole Food Nutrients

The Hidden Truth About Multivitamins - Synthetic vs. Whole Food Nutrients

Brad King, MS, MFS

In recent years, the use of multivitamins has become widespread, with nearly one in three North Americans taking these supplements daily. People purchase these nutrient concoctions believing they will benefit their health in some way. However, a growing body of research indicates that the majority of multivitamins do not improve health or promote longevity and may even be somewhat harmful.

A recent study from the National Cancer Institute, published in JAMA Network Open in June, found that daily multivitamin use was associated with a 4% increase in mortality risk[1]​. Like many other studies with primarily negative results, this one also used synthetically derived supplements. Any time you see a study using synthetic, isolated nutrients (i.e. not how they are found in food or nature) there is almost always a negative health outcome, yet none of these studies ever compare real whole food derived nutrients with their synthetic counterparts.

Understanding the differences between synthetic vitamins and those derived from real organic foods is crucial for making informed choices about our health and respecting the natural laws of nature, biochemistry and cellular biology[2].

Synthetic Vitamins - What You Need to Know

Isolation: Synthetic vitamins are isolated nutrients manufactured in a lab to mimic the molecular structure of natural vitamins. In other words, they may look the same under a microscope, but they do not behave the same inside our bodies (It’s pretty hard to fool millions of years of cellular evolution). Synthesizing nutrients from starting materials like petroleum[3] or genetically modified corn[4], and then delivering them in an isolated format, is unnatural and excludes the complex matrix of co-factors found in real foods[5].

Bioavailability: Synthetic vitamins are—more often than not—poorly recognized by the body, especially compared to natural whole food derived vitamins. They often lack the necessary co-factors that aid in absorption and utilization[6]​.

Label Indicators: Synthetic vitamins typically have chemical names ending in "ide", "ate" or “acid” (e.g., pyridoxine hydrochloride, thiamine mononitrate, ascorbic acid, folic acid). These names indicate a laboratory creation rather than a food-based source.

Whole Food Vitamins - What You Need to Know

Nutrient Synergy: Whole food vitamins come from natural sources such as fruits, vegetables, and mushrooms. They are part of a complex matrix of nutrients that work synergistically. For instance, vitamin C found in an orange is accompanied by bioflavonoids, enzymes, and other co-factors that enhance its effectiveness[7],[8], and vitamin E is found with eight isomers in food, rather than one[9].

Cellular Recognition: Our cells instantly recognize and utilize nutrients from whole foods more efficiently. These nutrients are delivered in forms and combinations that the body has evolved to process over millennia​[10].

Label Indicators: Supplements derived from whole foods will list the actual foods they come from (e.g., acerola cherry, spinach, shiitake mushrooms) rather than chemical names (LeafSource® Real Multi).

Recognizing Synthetic Supplements

Aspect

Synthetic Supplements

Whole Food Supplements

Label Indicators

Chemical names ending in "ide," "ate," or "acid"

Lists actual foods the nutrients are derived from

Example

Pyridoxine hydrochloride, thiamine mononitrate, ascorbic acid, folic acid

Vitamin C from acerola cherry, vitamin E from sunflower seeds, folate from spinach

Production

Manufactured in labs from petroleum, acetone, isophytol, corn, etc.,

Extracted from real fruits, vegetables, and mushrooms

Nutrient Delivery

Isolated nutrients

Nutrients delivered in a complex matrix with co-factors as found in nature/food

Bioavailability

Often less recognized and utilized by the body

Easily recognized and utilized by the body

 

The Dangers of Supraphysiological Levels

One of the pitfalls of synthetic supplements is the tendency to provide nutrients at supraphysiological levels - meaning many times higher than the recommended daily allowances (RDAs). While it might seem beneficial to get more vitamins, the body is not designed to handle such high concentrations[11]. Nutrients from real foods are supplied in much lower, yet more balanced levels, which the body can use more effectively​.

Conclusion

So, while synthetic multivitamins are convenient, cost effective, and thereby the most widely sold by supplement manufacturers (profits anyone!?), from a cellular and biochemical perspective, they simply cannot offer the same benefits as vitamins derived from whole foods, which the body can instantly recognize and use. The natural complexity and synergy of nutrients in real whole foods are essential for proper absorption, transport and utilization.

When choosing supplements, it becomes vital to opt for those derived from real – preferably organic – foods (LeafSource® Real Multi), and avoid synthetic, isolated nutrients (in this case, otherwise known as chemicals). By doing so, we can better support our health at a cellular level, in a way that truly aligns with how our bodies naturally process nutrients. After all, you can’t fool the body no matter how many times you try!

 

References:

 

[1] Loftfield E, et al. Multivitamin Use and Mortality Risk in 3 Prospective US Cohorts, Nutrition, Obesity, and Exercise. Jama network open, (2024) June 26, 2024
[2] Lindschinger, M.et al. (2019). A randomized pilot trial to evaluate the bioavailability of natural versus synthetic vitamin b complexes in healthy humans and their effects on homocysteine, oxidative stress, and antioxidant levels. Oxidative Medicine and Cellular Longevity, 2019, 1-14. https://doi.org/10.1155/2019/6082613
[3] Sun, L., Kwak, S., & Liu, J. (2019). Vitamin a production by engineered saccharomyces cerevisiae from xylose via two-phase in situ extraction. Acs Synthetic Biology, 8(9), 2131-2140. https://doi.org/10.1021/acssynbio.9b00217
[4] Chung, H. and Fields, M. L. (1986). Production of riboflavin and vitamin b12 by bacillus megaterium atcc 13639 and enterobacter aerogenes in corn meal. Journal of Food Science, 51(6), 1514-1517. https://doi.org/10.1111/j.1365-2621.1986.tb13848.x
[5] Northrop-Clewes and Thurnham "The Discovery and Characterization of Riboflavin" Annals of nutrition and metabolism (2012) doi:10.1159/000343111
[6] Carr, A. C. and Vissers, M. C. (2013). Synthetic or food-derived vitamin c—are they  equally bioavailable?. Nutrients, 5(11), 4284-4304. https://doi.org/10.3390/nu5114284
[7] Esquivel, M. (2022). Nutrition benefits and considerations for whole foods plant-based eating patterns. American Journal of Lifestyle Medicine, 16(3), 284-290. https://doi.org/10.1177/15598276221075992
[8] Liu, R. H. (2013). Health-promoting components of fruits and vegetables in the diet. Advances in Nutrition, 4(3), 384S-392S. https://doi.org/10.3945/an.112.003517
[9] Gázquez, A., et al, E. (2023). Natural vitamin e supplementation during pregnancy in rats increases rrr-α-tocopherol stereoisomer proportion and enhances fetal antioxidant capacity, compared to synthetic vitamin e administration. Annals of Nutrition and Metabolism, 79(2), 228-237. https://doi.org/10.1159/000529375
[10] Thompson, S. N., Redak, R. A., & Wang, L. (2005). Nutrition interacts with parasitism to influence growth and physiology of the insectmanduca sextal.. Journal of Experimental Biology, 208(4), 611-623. https://doi.org/10.1242/jeb.01404
[11] Mayengbam, S., et al. (2019). Metabolic consequences of discretionary fortified beverage consumption containing excessive vitamin b levels in adolescents. Plos One, 14(1), e0209913. https://doi.org/10.1371/journal.pone.0209913

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